The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 06, 2014
Filed:
Apr. 11, 2008
Pasi A. Janne, Newton, MA (US);
Jeffrey Engelman, Chestnut Hill, MA (US);
Lewis C. Cantley, Cambridge, MA (US);
Pasi A. Janne, Newton, MA (US);
Jeffrey Engelman, Chestnut Hill, MA (US);
Lewis C. Cantley, Cambridge, MA (US);
The General Hospital Corporation, Boston, MA (US);
Dana Farber Cancer Institute, Boston, MA (US);
Beth Israel Deaconess Medical Center, Boston, MA (US);
Abstract
Provided herein are methods for treating cancer that is resistant to treatment with an anti-ErbB therapeutic agent and which is associated with an activating MET gene mutation or a MET gene amplification. The methods involve administering to a subject a combination of an anti-ErbB therapeutic and an anti-MET therapeutic. Also provided are methods for reducing ErbB mediated signaling or PI3 kinase mediated signaling in a cancer cell.