The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 29, 2014
Filed:
Dec. 08, 2010
Xiaomei Jin, Oceanside, CA (US);
Lei Yu, Oceanside, CA (US);
Hirokazu Takahashi, Sapporo, JP;
Yasunobu Tanaka, Sapporo, JP;
Yoshiro Niitsu, Sapporo, JP;
Elena Feinstein, Rehovot, IL;
Sharon Avkin-nachum, Nes Ziona, IL;
Hagar Kalinski, Rishon Le-Zion, IL;
Igor Mett, Rehovot, IL;
Shai Erlich, Belmont, CA (US);
Elizabeth C. Squiers, Half Moon Bay, CA (US);
Ning Chen, Pittsburgh, PA (US);
Xiaomei Jin, Oceanside, CA (US);
Lei Yu, Oceanside, CA (US);
Hirokazu Takahashi, Sapporo, JP;
Yasunobu Tanaka, Sapporo, JP;
Yoshiro Niitsu, Sapporo, JP;
Elena Feinstein, Rehovot, IL;
Sharon Avkin-Nachum, Nes Ziona, IL;
Hagar Kalinski, Rishon Le-Zion, IL;
Igor Mett, Rehovot, IL;
Shai Erlich, Belmont, CA (US);
Elizabeth C. Squiers, Half Moon Bay, CA (US);
Ning Chen, Pittsburgh, PA (US);
Nitto Denko Corporation, Osaka, JP;
Abstract
Provided herein are compositions, methods and kits for modulating expression of target genes, particularly heat shock protein 47 (hsp47). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA) or short hairpin RNA (shRNA)) that modulate a gene encoding hsp47, for example, the gene encoding human hsp47. The composition and methods disclosed herein may also be used in treating conditions and disorders associated with hsp47 such as liver fibrosis, pulmonary fibrosis, peritoneal fibrosis and kidney fibrosis.