The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 29, 2014
Filed:
Aug. 26, 2005
Use of tris(hydroxymethyl) aminomethane for the stabilization of peptides, polypeptides and proteins
Applicants:
Ingun Christiansen, Birkerod, DK;
Arne Staby, Bagsvaerd, DK;
Inventors:
Ingun Christiansen, Birkerod, DK;
Arne Staby, Bagsvaerd, DK;
Assignee:
Novo Nordisk A/S, Bagsvaerd, DK;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/28 (2006.01); C07K 5/00 (2006.01); C07K 7/00 (2006.01); C07K 16/00 (2006.01); C07K 17/00 (2006.01); C07K 2/00 (2006.01); C07K 4/00 (2006.01); A61K 38/26 (2006.01); C07K 1/00 (2006.01); C07K 1/113 (2006.01);
U.S. Cl.
CPC ...
C07K 1/113 (2013.01);
Abstract
The present invention is directed to a method for reducing the onset or incidence of gelation/fibrillation/aggregation during the up- and down-stream processing and purification of peptides, polypeptides and proteins analogs and/or derivatives thereof, including Glucagon-Like Peptides (GLPs). More particularly, the present invention relates to methods of processing and purifying such peptides, polypeptides and proteins in the presence of tris(hydroxymethyl)aminomethane.