The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 29, 2014

Filed:

Feb. 04, 2012
Applicants:

Christopher Waters, East Lansing, MI (US);

Karthik Sambanthamoorthy, Lansing, MI (US);

Matthew Neiditch, Princeton Junction, NJ (US);

Martin Semmelhack, Princeton, NJ (US);

Inventors:

Christopher Waters, East Lansing, MI (US);

Karthik Sambanthamoorthy, Lansing, MI (US);

Matthew Neiditch, Princeton Junction, NJ (US);

Martin Semmelhack, Princeton, NJ (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/44 (2006.01); A61K 31/415 (2006.01); C07D 401/12 (2006.01); C07D 235/28 (2006.01);
U.S. Cl.
CPC ...
Abstract

The various embodiments relate to a compound comprising: wherein R, R, R, R, R, R, R, R, R, R, R, and Rare each independently hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclyl, alkoxy, aryloxy, heteroaryloxy, alkoxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, alkylsulfonyl, arylsulfonyl, aminosulfonyl, alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, acyl, acylamino, amino, alkylamino, dialkylamino, arylamino, carboxylate (—COH), cyano, nitro, —CONH2, heteroarylamino, oxime, alkyloxime, aryloxime, amino-oxime or halogen when A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, and Q are carbon, and X is O, NR (where R is hydrogen, alkyl, aryl or acyl), S, SO (sulfoxide), SO(sulfone), or C(R)(where R=H, alkyl, aryl, alkenyl, alkynyl, or acyl); or wherein R, R, R, R, R, R, R, R, R, R, R, and Rare each independently hydrogen or hydroxyl when A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, and Q are each independently nitrogen, and compositions, combinations, pharmaceutically acceptable salts, esters, and prodrugs thereof. The invention also relates to methods of using such compounds and compositions.


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