The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 29, 2014
Filed:
Dec. 04, 2009
Axel Becker, Darmstadt, DE;
Clemens Kuehn, Darmsatdt, DE;
Christoph Saal, Otzberg, DE;
Oliver Schadt, Rodenbach, DE;
Dieter Dorsch, Ober-Ramstadt, DE;
Heinz Hermann Bokel, Darmstadt, DE;
Frank Stieber, Heidelberg, DE;
Cristina Donini, Geneva, IT;
Axel Becker, Darmstadt, DE;
Clemens Kuehn, Darmsatdt, DE;
Christoph Saal, Otzberg, DE;
Oliver Schadt, Rodenbach, DE;
Dieter Dorsch, Ober-Ramstadt, DE;
Heinz Hermann Bokel, Darmstadt, DE;
Frank Stieber, Heidelberg, DE;
Cristina Donini, Geneva, IT;
MERCK PATENT GmbH, Darmstadt, DE;
Abstract
Compounds of the present invention concern 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile hydrochloride solvates and crystalline modifications thereof. The compound, 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile, has the following structural formula: The hydrochloride solvates and crystalline modifications thereof according to the invention are useful for treatment of physiological and/or pathophysiological conditions, such as cancer, that are caused, mediated and/or propagated by the inhibition, regulation and/or modulation of signal transduction of kinases, in particular by the inhibition of tyrosine kinases, especially Met-kinase. The present invention further relates to processes of manufacturing these crystalline modifications.