The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 29, 2014
Filed:
Jan. 21, 2011
Claude Michel Wischik, Aberdeen, GB;
Janet Elizabeth Rickard, Aberdeen, GB;
Charles Robert Harrington, Aberdeen, GB;
David Horsley, Aberdeen, GB;
John Mervyn David Storey, Old Aberdeen, GB;
Colin Marshall, Old Aberdeen, GB;
James Peter Sinclair, Old Aberdeen, GB;
Thomas Craven Baddeley, Old Aberdeen, GB;
Claude Michel Wischik, Aberdeen, GB;
Janet Elizabeth Rickard, Aberdeen, GB;
Charles Robert Harrington, Aberdeen, GB;
David Horsley, Aberdeen, GB;
John Mervyn David Storey, Old Aberdeen, GB;
Colin Marshall, Old Aberdeen, GB;
James Peter Sinclair, Old Aberdeen, GB;
Thomas Craven Baddeley, Old Aberdeen, GB;
Wis Ta Laboratories Ltd., Singapore, SG;
Abstract
This invention pertains generally to the field of phenothiazine compounds, and more particularly to certain stably reduced phenothiazine compounds, specifically, certain 3,7-diamino-10H-phenothiazine (DAPTZ) compounds of the following formula: wherein: each of Rand Ris independently selected from: —H; Calkyl; Calkenyl; and halogenated Calkyl; each of Rand Ris independently selected from: —H; Calkyl; Calkenyl; and halogenated Calkyl; each of Rand Ris independently selected from: —H; Calkyl; Calkenyl; and halogenated Calkyl; each of HXand HXis independently a protic acid; and pharmaceutically acceptable salts, solvates, and hydrates thereof. These compounds are useful as drugs, for example, in the treatment of tauopathies, such as Alzheimer's disease, and also as prodrugs for the corresponding oxidized thioninium drugs (for example, methylthioninium chloride, MTC).