The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 29, 2014
Filed:
Oct. 23, 2012
Stephan Maurer, Neustadt-Gimmeldingen, DE;
Bernhard Hauer, Fussgönheim, DE;
Melanie Bonnekessel, Mannheim, DE;
Kurt Faber, Graz, AT;
Clemens Stückler, Graz, AT;
Stephan Maurer, Neustadt-Gimmeldingen, DE;
Bernhard Hauer, Fussgönheim, DE;
Melanie Bonnekessel, Mannheim, DE;
Kurt Faber, Graz, AT;
Clemens Stückler, Graz, AT;
BASF SE, , DE;
Abstract
A process for the enzymatic reduction of an enoate (1) wherein the C═C bond of the enoate (1) is stereoselectively hydrogenated in the presence of an enoate-reductase and an oxidizable co-substrate (2) in a system which is free of NAD(P)H, in which A is a ketone radical (—CRO), an aldehyde radical (—CHO), a carboxyl radical (—COOR), with R═H or optionally substituted C-C-alkyl radical, R, Rand Rare independently of one another H, —O—C-C-alkyl, —O—W with W=a hydroxyl protecting group, C-C-alkyl, which can be substituted, C-C-alkenyl, carboxyl, or an optionally substituted carbo- or heterocyclic, aromatic or nonaromatic radical, or one of R, Rand Ris a —OH radical, or Ris linked to Rso as to become part of a 4-8-membered cycle, or Ris linked to R so as to become part of a 4-8-membered cycle, with the proviso that R, Rand Rmay not be identical.