The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8709721 B1

PDF
Full Text
Expired
Date of Patent:
Apr. 29, 2014

Filed:

Oct. 01, 2010
Applicants:

Hiroshi Abe, Saitama, JP;

Yoshihiro Ito, Saitama, JP;

Aya Shibata, Saitama, JP;

Mika Ito, Saitama, JP;

Inventors:

Hiroshi Abe, Saitama, JP;

Yoshihiro Ito, Saitama, JP;

Aya Shibata, Saitama, JP;

Mika Ito, Saitama, JP;

Assignee:

Riken, Wako, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2006.01); C07D 409/00 (2006.01); C07H 19/04 (2006.01);
U.S. Cl.
CPC ...
Abstract

Provided are a fluorescent on/off switchable compound for a gene analysis, which is highly stable and highly sensitive, and enables amplification and observation of a trace gene signal, and a labeling reagent for detection of a bio-related material, which uses the fluorescent on/off switchable compound. A compound represented by the following formula (I'): wherein X is a hydrogen atom or a carboxylic acid-protecting group, Y is a 2,4-dinitrobenzenesulfonyl group, a 2-cyano-4-nitrobenzenesulfonyl group or a 5-nitropyridin-2-ylsulfonyl group, R, R, Rand Rare each independently a hydrogen atom, a halogen atom, a hydroxyl group, an alkyl group having a carbon number of 1 to 6, an alkoxy group having a carbon number of 1 to 6, an aryl group having a carbon number of 6 to 10, or a cyano group.


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