The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 29, 2014
Filed:
Jul. 05, 2011
Jennifer Jones, Palo Alto, CA (US);
Rosemarie Dekruyff, Stanford, CA (US);
Dale T. Umetsu, Newton, MA (US);
Gordon J. Freeman, Boston, MA (US);
Susan Jane Knox, Stanford, CA (US);
Jennifer Jones, Palo Alto, CA (US);
Rosemarie Dekruyff, Stanford, CA (US);
Dale T. Umetsu, Newton, MA (US);
Gordon J. Freeman, Boston, MA (US);
Susan Jane Knox, Stanford, CA (US);
The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA (US);
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
Children's Hospital Corporation, Boston, MA (US);
Abstract
A genetic locus and corresponding family of proteins associated with regulation of immune function and cell survival are provided. These genes encode cell surface molecules with conserved IgV and mucin domains. The locus comprising the TIM family is genetically associated with immune dysfunction, including asthma. Furthermore, the TIM gene family is located within a region of human chromosome 5 that is commonly deleted in malignancies and myelodysplastic syndrome. Polymorphisms in the gene sequences are associated with the development of airway hyperreactivity and allergic inflammation, and T cell production of IL-4 and IL-13. The proteins include the human hepatitis A cellular receptor, hHAVcr-1.