The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 22, 2014
Filed:
Dec. 24, 2009
Luhong Tang, Jiangsu, CN;
Ajuan Dai, Jiangsu, CN;
Ze Wang, Jiangsu, CN;
Yang Sun, Jiangsu, CN;
Xinning Liu, Jiangsu, CN;
Lingyan Xu, Jiangsu, CN;
Xin Fang, Jiangsu, CN;
Shuang Qiu, Jiangsu, CN;
Yaqing Cao, Jiangsu, CN;
Xiaomin Xu, Jiangsu, CN;
Ruixia Jiang, Jiangsu, CN;
Chao Wu, Jiangsu, CN;
Luhong Tang, Jiangsu, CN;
Ajuan Dai, Jiangsu, CN;
Ze Wang, Jiangsu, CN;
Yang Sun, Jiangsu, CN;
Xinning Liu, Jiangsu, CN;
Lingyan Xu, Jiangsu, CN;
Xin Fang, Jiangsu, CN;
Shuang Qiu, Jiangsu, CN;
Yaqing Cao, Jiangsu, CN;
Xiaomin Xu, Jiangsu, CN;
Ruixia Jiang, Jiangsu, CN;
Chao Wu, Jiangsu, CN;
Wuxi Hongrui Bio-Pharma-Tech Co., Ltd., Wuxi, Jiangsu, CN;
Other;
Abstract
The present invention designs and synthesizes the ascorbyl ester derivatives of the aryl (ethanoic) propanoic acid non-steroidal anti-inflammatory medicaments, such as ibuprofen, ketoprofen and naproxen, and addition salt of the derivatives with pharmaceutical acid or pharmaceutical alkaline. The non-steroidal anti-inflammatory medicament which takes the ibuprofen as the representative is a common antipyretic analgesic medicament. The invention has remarkable antipyretic and analgesic effects and good safety except for anti-inflammatory effect, thus being not only suitable for adults, but also suitable for the elderly people, infants and children. The aryl (ethanoic) propanoic acid ascorbyl ester can be converted into ascorbyl ester derivatives and the addition salts of the derivatives with pharmaceutical acid or pharmaceutical alkaline, which can improve the water solubility thereof, facilitate intravenously administration, reduce the onset time, improve the bioavailability, reduce the stimulation effect to gastrointestinal tract, and enhance the penetrating capacity to hemato encephalic barrier, and can be used as a novel medicament to be applied for antiphlogistic, antipyresis, analgesia, treatment of arthritis, dysmenorrheal, multiple sclerosis, pneumonia cystic fibrosis and patent ductus arteriosus of premature infants, and prevention and treatment of cerebral apoplexy, hypoxic-ischemic brain damage, senile dementia and certain cancers.