The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 22, 2014
Filed:
Jul. 01, 2011
Applicants:
Erno M. Keskeny, Wilmington, DE (US);
James J. Mencel, North Wales, PA (US);
Jen-sen Dung, Boothwyn, PA (US);
Inventors:
Erno M. Keskeny, Wilmington, DE (US);
James J. Mencel, North Wales, PA (US);
Jen-Sen Dung, Boothwyn, PA (US);
Assignee:
Johnson Matthey Public Limited Co., London, GB;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 489/02 (2006.01); C07D 489/04 (2006.01); C07D 489/08 (2006.01);
U.S. Cl.
CPC ...
Abstract
A method of preparing oxycodone includes forming 14-hydroxycodeine by reduction of 14-hydroxycodeinone and rearrangement of the 14-hydroxycodeine to form the oxycodone. During the reduction step, the ketone group of an undesirable contaminant precursor, 8,14-dihydroxy-7,8-dihydrocodeinone, is reduced to a hydroxyl group thus forming a triol. This triol is substantially inert with respect to reforming 14-hydroxycodeinone and can be readily separated from oxycodone.