The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 22, 2014
Filed:
Aug. 03, 2011
Applicants:
Subo Liao, Ballwin, MO (US);
Peter X. Wang, Creve Coeur, MO (US);
David W. Berberich, St. Peters, MO (US);
Douglas C. Miller, University City, MO (US);
Inventors:
Subo Liao, Ballwin, MO (US);
Peter X. Wang, Creve Coeur, MO (US);
David W. Berberich, St. Peters, MO (US);
Douglas C. Miller, University City, MO (US);
Assignee:
Mallinckrodt LLC, Hazelwood, MO (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 489/00 (2006.01); C07D 221/22 (2006.01); C07D 221/28 (2006.01); A61K 31/44 (2006.01); C07D 211/00 (2006.01); C07D 213/00 (2006.01); C07D 215/00 (2006.01); C07D 217/00 (2006.01); C07D 219/00 (2006.01); C07D 221/00 (2006.01); C07D 471/00 (2006.01); C07D 491/00 (2006.01); C07D 498/00 (2006.01); C07D 513/00 (2006.01); C07D 515/00 (2006.01); C07D 489/08 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention provides processes for the preparation of N-alkyl morphinans without the isolation of nor-morphinan intermediates. In particular, the invention provides tandem hydrolysis/alkylation reactions for the synthesis of N-alkyl morphinans.