The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 22, 2014

Filed:

Oct. 15, 2010
Applicants:

Melissa Dumble, Collegeville, PA (US);

Rakesh Kumar, Collegeville, PA (US);

Sylvie Laquerre, Collegeville, PA (US);

Peter Lebowitz, Collegeville, PA (US);

Inventors:

Melissa Dumble, Collegeville, PA (US);

Rakesh Kumar, Collegeville, PA (US);

Sylvie Laquerre, Collegeville, PA (US);

Peter Lebowitz, Collegeville, PA (US);

Assignee:

GlaxoSmithKline LLC, Philadelphia, PA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/506 (2006.01); A61K 31/519 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
Abstract

A novel combination comprising the MEK inhibitor N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)6,8-dimethyl;-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, with a B-Raf inhibitor, particularly N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophen-}-2,6-difluorobenzenesulfonamide or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which the inhibition of MEK and/or B-Raf is beneficial, eg. cancer.


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Dumble, Melissa. (2014). Pharmaceutical combination of mek inhibitor and b-raf inhibitors (U.S. Patent No. 8703781). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/8703781

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