The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 22, 2014
Filed:
Apr. 29, 2011
Applicants:
Svetlana O. Doronina, Snohomish, WA (US);
Peter D. Senter, Seattle, WA (US);
Brian E. Toki, Shoreline, WA (US);
Toni Beth Kline, Seattle, WA (US);
Inventors:
Svetlana O. Doronina, Snohomish, WA (US);
Peter D. Senter, Seattle, WA (US);
Brian E. Toki, Shoreline, WA (US);
Toni Beth Kline, Seattle, WA (US);
Assignee:
Seattle Genetics, Inc., Bothell, WA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/08 (2006.01); A61K 47/48 (2006.01);
U.S. Cl.
CPC ...
Abstract
Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.