The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 22, 2014
Filed:
Mar. 18, 2011
Donald J. Buchsbaum, Alabaster, AL (US);
Albert F. Lobuglio, Birmingham, AL (US);
Tong Zhou, Birmingham, AL (US);
Kimberly Foreman, Clarendon Hills, IL (US);
Donald J. Buchsbaum, Alabaster, AL (US);
Albert F. Lobuglio, Birmingham, AL (US);
Tong Zhou, Birmingham, AL (US);
Kimberly Foreman, Clarendon Hills, IL (US);
The UAB Research Foundation, Birmingham, AL (US);
Abstract
Provided is a method of determining the level of resistance or sensitivity of cancer stem cells to a death receptor agonist. The method includes detecting the level of IAP in one or more DR5/DDX3/IAP complexes in or from the cancer stem cells. Also provided is a method of killing cancer stem cells in a subject and a method of reducing the risk of cancer recurrence in a subject.