The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 22, 2014
Filed:
Jul. 16, 2009
Thomas P. Sakmar, New York, NY (US);
Santosh T. Menon, Edgewater, NJ (US);
Neeraj Kapoor, New York, NY (US);
Ruchi Gupta, New York, NY (US);
Dan Raleigh, Stony Brook, NY (US);
Thomas P. Sakmar, New York, NY (US);
Santosh T. Menon, Edgewater, NJ (US);
Neeraj Kapoor, New York, NY (US);
Ruchi Gupta, New York, NY (US);
Dan Raleigh, Stony Brook, NY (US);
The Rockefeller University, New York, NY (US);
The Research Foundation of State University of New York, Albany, NY (US);
Abstract
The invention relates to Nucleobindin-1 (NUCB1) protein variants that are capable of disaggregating amyloid fibrils as well as inhibiting the formation of fibrils in the presence of physiological concentrations of calcium. Isolated NUCB1 protein variants, nucleic acids encoding the protein variants, cells comprising the isolated nucleic acids, pharmaceutical compositions and kits comprising the variants, methods of making the variants, and therapeutic uses of the variants are provided.