The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 22, 2014
Filed:
Nov. 18, 2009
Jing Huang, Los Angeles, CA (US);
Brett Eugene Lomenick, Los Angeles, CA (US);
Rui Hao, Los Angeles, CA (US);
Nao Jonai, Yokohama, JP;
Thomas M. Vondriska, Los Angeles, CA (US);
Sarah Warburton, Los Angeles, CA (US);
Gregory Joseph Baker, Los Angeles, CA (US);
Mariam Aghajan, Los Angeles, CA (US);
Jing Huang, Los Angeles, CA (US);
Brett Eugene Lomenick, Los Angeles, CA (US);
Rui Hao, Los Angeles, CA (US);
Nao Jonai, Yokohama, JP;
Thomas M. Vondriska, Los Angeles, CA (US);
Sarah Warburton, Los Angeles, CA (US);
Gregory Joseph Baker, Los Angeles, CA (US);
Mariam Aghajan, Los Angeles, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
Drug affinity responsive target stability (DARTS) is a method of drug target ID with several significant advantages over current techniques. In certain embodiments the method involves contacting a sample comprising one or more protein target(s) with a test agent to form a sample/test agent mixture; contacting the mixture with a protease; and identifying a protein or protein fragment that is protected from proteolysis, wherein the protection from proteolysis is an indicator that the protein or protein fragment binds to or interacts with the test agent.