The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 22, 2014
Filed:
Sep. 08, 2010
Young IL Yeom, Daejeon, KR;
BO Hwa Sohn, Daejeon, KR;
IN Young Park, Daejeon, KR;
Jung Ju Lee, Daejeon, KR;
Yejin Jang, Daejeon, KR;
Suk-jin Yang, Daejeon, KR;
Kyung Chan Park, Daejeon, KR;
Hyang-sook Yoo, Daejeon, KR;
Jong Young Choi, Seoul, KR;
Young Il Yeom, Daejeon, KR;
Bo Hwa Sohn, Daejeon, KR;
In Young Park, Daejeon, KR;
Jung Ju Lee, Daejeon, KR;
Yejin Jang, Daejeon, KR;
Suk-jin Yang, Daejeon, KR;
Kyung Chan Park, Daejeon, KR;
Hyang-sook Yoo, Daejeon, KR;
Jong Young Choi, Seoul, KR;
Korea Research Institute of Bioscience and Biotechnology, Daejeon, KR;
Abstract
The present invention relates to a method for the diagnosis and prognosis of cancers using an epigenetic marker consisting of a specific single CpG site in TTP (Tristetraprolin) promoter and treatment of cancers by regulating its epigenetic status. Particularly, the present invention relates to a method for the diagnosis and prognosis of liver cancer by measuring specific methylation of C, the 32residue of the nucleic acid sequence represented by SEQ. ID. NO. 41, and a method for treatment of cancer by regulating the same. The present invention can be effectively used for the diagnosis and/or treatment of liver cancer characterized by TTP down-regulation and methylation of C, the 32residue of the nucleic acid sequence represented by SEQ. ID. NO. 41. The present invention can be further applied for the diagnosis and treatment of other cancers or inflammatory diseases that are characterized by TTP down-regulation and methylation of C, the 32residue of the nucleic acid sequence represented by SEQ. ID. NO. 41.