The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 22, 2014
Filed:
Aug. 23, 2011
Applicants:
Charles Rice, New York, NY (US);
Matthew J. Evans, New York, NY (US);
Thomas Von Hahn, Hamburg, DE;
Inventors:
Assignee:
The Rockefeller University, New York, NY (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/29 (2006.01); A61K 39/395 (2006.01); C07K 16/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
The invention relates to the discovery that the Claudin-1 protein functions as a co-receptor for entry of HCV into cells. Methods of inhibiting, preventing or mitigating HCV infections by inhibiting HCV interactions with Claudin-1 are provided. Methods of identifying agents or compounds that interfere with HCV interactions with Claudin-1 are also provided. Finally, useful kits, cell culture compositions, agents, and compounds related to the inhibition of HCV interactions with Claudin-1 are also disclosed.