The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 15, 2014
Filed:
Sep. 28, 2012
Vertex Pharmaceuticals Incorporated, Boston, MA (US);
David Bebbington, Newbury, GB;
Jean-Damien Charrier, Wantage, GB;
Julian Golec, Faringdon, GB;
Francoise Pierard, Abingdon, GB;
Vertex Pharmaceuticals Incorporated, Cambridge, MA (US);
Abstract
This invention describes novel pyrazole compounds of formula III: wherein Z, Z, and Zare as described in the specification; Q is —S—, —O—, —N(R)—, or —CH(R)—; Ris T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; and Rand R'are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.