The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 15, 2014
Filed:
Nov. 18, 2009
Jeffrey Michael Axten, Collegeville, PA (US);
Charles William Blackledge, Jr., Collegeville, PA (US);
Gerald Patrick Brady, Jr., Collegeville, PA (US);
Yanhong Feng, Collegeville, PA (US);
Seth W. Grant, Collegeville, PA (US);
Jesus Raul Medina, Collegeville, PA (US);
William H. Miller, Collegeville, PA (US);
Stuart P. Romeril, Collegeville, PA (US);
Jeffrey Michael Axten, Collegeville, PA (US);
Charles William Blackledge, Jr., Collegeville, PA (US);
Gerald Patrick Brady, Jr., Collegeville, PA (US);
Yanhong Feng, Collegeville, PA (US);
Seth W. Grant, Collegeville, PA (US);
Jesus Raul Medina, Collegeville, PA (US);
William H. Miller, Collegeville, PA (US);
Stuart P. Romeril, Collegeville, PA (US);
GlaxoSmithKline LLC, Wilmington, DE (US);
Abstract
The invention is directed to 6-(4-pyrimidinyl)-1H-indazole derivatives. Specifically, the invention is directed to compounds according to Formula (I) wherein R-Rare defined herein. The compounds of the invention axe inhibitors of PDK1 and can be useful in the treatment of immune and metabolic diseases and disorders characterized by constitutively activated ACG kinases such as cancer and more specifically cancers of the breast, colon, and lung. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting PDK1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.