The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 15, 2014
Filed:
May. 21, 2010
Fusuke Mazuka, Odawara, JP;
Takayoshi Fukushima, Odawara, JP;
Naomi Sumida, Odawara, JP;
Koji Yanai, Odawara, JP;
Fusuke Mazuka, Odawara, JP;
Takayoshi Fukushima, Odawara, JP;
Naomi Sumida, Odawara, JP;
Koji Yanai, Odawara, JP;
Meiji Seika Pharma Co., Ltd., Tokyo, JP;
Abstract
Disclosed are a ketoreductase mutant which can be used for an efficient production of daunorubicin derivatives, a DNA encoding the mutant, a transformant prepared by introducing the DNA thereinto to produce a daunorubicin derivative, and a process of producing a daunorubicin derivative using the transformant. The ketoreductase mutant has an amino acid sequence in which one amino acid residue or two or more amino acid residues selected from the group consisting of amino acids located at positions corresponding to the 42nd, 149th, 153rd, 270th, and 306th amino acids in the amino acid sequence of a ketoreductase (EvaE) from a chlororemomycin-producing bacterium () are substituted with another amino acid residues.