The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 15, 2014
Filed:
Jul. 25, 2011
William Dall'acqua, Gaithersburg, MD (US);
Herren Wu, Boyds, MD (US);
Melissa Damschroder, Germantown, MD (US);
Jose Casas-finet, Gaithersburg, MD (US);
William Dall'Acqua, Gaithersburg, MD (US);
Herren Wu, Boyds, MD (US);
Melissa Damschroder, Germantown, MD (US);
Jose Casas-Finet, Gaithersburg, MD (US);
MedImmune, LLC, Gaithersburg, MD (US);
Abstract
The present invention relates to novel molecules (Fc variants) comprising at least one antigen binding region and an Fc region that further comprises a modified hinge which alters the binding of Fc to one or more Fc ligand (e.g., FcγRs) and/or modulates effector function. More specifically, this invention provides Fc variants that have modified binding affinity to one or more FcγR and/or C1q. Additionally, the Fc variants have altered antibody-dependent cell-mediated cytotoxicity (ADCC) and/or complement dependent cytotoxicity (CDC) activity. The invention further provides methods and protocols for the application of said Fc variants particularly for therapeutic purposes.