The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 15, 2014
Filed:
Nov. 06, 2009
Alicja Bielawska, Charleston, SC (US);
Aiping Bai, Charleston, SC (US);
Zdzislaw M. Szulc, Charleston, SC (US);
Yusuf A. Hannun, Sullivan's Island, SC (US);
James S. Norris, Mount Pleasant, SC (US);
Liu Xiang, Mount Pleasant, SC (US);
Alicja Bielawska, Charleston, SC (US);
Aiping Bai, Charleston, SC (US);
Zdzislaw M. Szulc, Charleston, SC (US);
Yusuf A. Hannun, Sullivan's Island, SC (US);
James S. Norris, Mount Pleasant, SC (US);
Liu Xiang, Mount Pleasant, SC (US);
MUSC Foundation for Research Development, Charleston, SC (US);
Abstract
The presently disclosed subject matter provides compounds of the formula, formula (Ia): and pharmaceutically acceptable salts thereof, wherein R, R, R, R, R, X, Y, and n are as defined herein. Also disclosed are methods for making the compounds of the formula as set forth hereinabove, their use in inhibiting acid ceramidase and ceramidase-related activity, and their use as drugs and prodrugs in the treatment and/or prevention of diseases associated with undesirable ceramidase or sphingosine kinase activity, including, but not limited to, cancer, cancer metastasis, atherosclerosis, stenosis, inflammation, asthma, and atopic dermatitis.