The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 15, 2014
Filed:
Sep. 02, 2009
Mark E. Shirtliff, Ellicott City, MD (US);
Rebecca A. Brady, Laurel, MD (US);
Jeffrey G. Leid, Flagstaff, AZ (US);
Timothy L. Vail, Parks, AZ (US);
Jennifer M. Kofonow, Philadelphia, PA (US);
Mark E. Shirtliff, Ellicott City, MD (US);
Rebecca A. Brady, Laurel, MD (US);
Jeffrey G. Leid, Flagstaff, AZ (US);
Timothy L. Vail, Parks, AZ (US);
Jennifer M. Kofonow, Philadelphia, PA (US);
University of Maryland, Baltimore, Baltimore, MD (US);
Arizona Board of Regents A Body Corporate of the State of Arizona, Flagstaff, AZ (US);
Abstract
The present invention relates to a method for in vivo detection of a biofilm infection residing in a mammal, the method comprising (i) administering to the mammal a diagnostic-effective amount of a biofilm-specific probe, wherein the probe comprises a bio film-targeting moiety and a paramagnetic nanoparticle core; and (ii) imaging the mammal to detect the presence of the biofilm infection by observing the mammal using a magnetic resonance diagnostic technique after the biofilm-specific probe has been provided sufficient time to selectively bind to the bio film infection that may be present in the mammal. The invention also relates to methods of treatment of a bio film infection, and compositions and kits useful in the detection and/or treatment of bio film infections.