The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 15, 2014
Filed:
Jul. 28, 2009
Katsumi Yabusaki, Hamamatsu, JP;
Katsumi Yabusaki, Hamamatsu, JP;
Kowa Company, Ltd., Nagoya-shi, Aichi, JP;
Abstract
Disclosed is a measurement method which can largely reduce the time required for the detection of a physiologically active substance derived from an organism (e.g., an endotoxin, β-D-glucan) or the determination of the concentration of the physiologically active substance by utilizing the reaction between the physiologically active substance and LAL. Also disclosed is a measurement apparatus utilizing the measurement method. An incident light from a light source is focused onto a sample and delivered to the sample to cause the bombardment with coagulin which is a final product of a protease cascade (i.e., a coagulin monomer) and an extremely fine aggregate which is produced by the aggregation of the coagulin monomers (i.e. a coagulin aggregate), thereby generating a scattered light. The scattered light is detected by a light-receiving element. The concentration of the endotoxin can be determined based on the initial rate of increase in the scattered light detected.