The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 15, 2014
Filed:
Mar. 02, 2011
Wei Qian, Ann Arbor, MI (US);
Makoto Murakami, Ann Arbor, MI (US);
Yuki Ichikawa, Ann Arbor, MI (US);
Yong Che, Ann Arbor, MI (US);
Wei Qian, Ann Arbor, MI (US);
Makoto Murakami, Ann Arbor, MI (US);
Yuki Ichikawa, Ann Arbor, MI (US);
Yong Che, Ann Arbor, MI (US);
IMRA America, Inc., Ann Arbor, MI (US);
Abstract
In the present invention, a method of producing stable bare colloidal gold nanoparticles is disclosed. The nanoparticles can subsequently be subjected to partial or full surface modification. The method comprises preparation of colloidal gold nanoparticles in a liquid by employing a top-down nanofabrication method using bulk gold as a source material. The surface modification of these nanoparticles is carried out by adding one or multiple types of ligands each containing functional groups which exhibit affinity for gold nanoparticle surfaces to produce the conjugates. Because of the high efficiency and excellent stability of the nanoparticles produced by this method, the fabricated gold nanoparticle conjugates can have surface coverage with functional ligands which can be tuned to be any percent value between 0 and 100%.