The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 15, 2014
Filed:
May. 08, 2012
Jon H. Condra, Doylestown, PA (US);
Rose M. Cubbon, Fanwood, NJ (US);
Holly A. Hammond, Telford, PA (US);
Laura Orsatti, Ponezia, IT;
Shilpa Pandit, Edison, NJ (US);
Laurence B. Peterson, Westfield, NJ (US);
Joseph C. Santoro, Belle Mead, NJ (US);
Ayesha Sitlani, Metuchen, MA (US);
Dana D. Wood, Collegeville, PA (US);
Henryk Mach, Amber, PA (US);
Heidi Pixley, Glenside, PA (US);
Sonia M. Gregory, Charlottesville, VA (US);
Jeffrey T. Blue, Telford, PA (US);
Kevin Wang, Lansdale, PA (US);
Peizhi (Peter) Luo, Lansdale, PA (US);
Denise K. Nawrocki, Annandale, NJ (US);
Pingyu Zhong, Blue Bell, PA (US);
Feng Dong, Lansdale, PA (US);
Yan LI, San Jose, CA (US);
Jon H. Condra, Doylestown, PA (US);
Rose M. Cubbon, Fanwood, NJ (US);
Holly A. Hammond, Telford, PA (US);
Laura Orsatti, Ponezia, IT;
Shilpa Pandit, Edison, NJ (US);
Laurence B. Peterson, Westfield, NJ (US);
Joseph C. Santoro, Belle Mead, NJ (US);
Ayesha Sitlani, Metuchen, MA (US);
Dana D. Wood, Collegeville, PA (US);
Henryk Mach, Amber, PA (US);
Heidi Pixley, Glenside, PA (US);
Sonia M. Gregory, Charlottesville, VA (US);
Jeffrey T. Blue, Telford, PA (US);
Kevin Wang, Lansdale, PA (US);
Peizhi (Peter) Luo, Lansdale, PA (US);
Denise K. Nawrocki, Annandale, NJ (US);
Pingyu Zhong, Blue Bell, PA (US);
Feng Dong, Lansdale, PA (US);
Yan Li, San Jose, CA (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
Antagonists of human proprotein convertase subtilisin-kexin type 9 ('PCSK9') are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.