The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 08, 2014
Filed:
May. 11, 2010
Christopher Paul Larch, Old Aberdeen, GB;
John Mervyn David Storey, Old Aberdeen, GB;
Craig Williamson, Old Aberdeen, GB;
Colin Marshall, Old Aberdeen, GB;
Steven John Kemp, Old Aberdeen, GB;
Christopher Paul Larch, Old Aberdeen, GB;
John Mervyn David Storey, Old Aberdeen, GB;
Craig Williamson, Old Aberdeen, GB;
Colin Marshall, Old Aberdeen, GB;
Steven John Kemp, Old Aberdeen, GB;
Wista Laboratories Ltd., Singapore, SG;
Abstract
Described are methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as 'diaminophenothiazinium compounds') including Methylhioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: a thiosulfonic acid formation (TSAF); an oxidative coupling (OC); and a ring closure (RC). Also described are resulting compounds and compositions comprising them (e.g., tablets, capsules) for use in methods of medical treatment and diagnosis, etc., for example, for tauopathies, or Alzheimer's disease (AD).