The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 08, 2014

Filed:

Jan. 13, 2011
Applicants:

Zi-jian Xie, Saline, MI (US);

Qiqi YE, Toledo, OH (US);

Zhichuan LI, Toledo, OH (US);

Inventors:

Zi-Jian Xie, Saline, MI (US);

Qiqi Ye, Toledo, OH (US);

Zhichuan Li, Toledo, OH (US);

Assignee:

The University of Toledo, Toledo, OH (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 7/08 (2006.01); A61K 38/04 (2006.01);
U.S. Cl.
CPC ...
Abstract

This invention is based in part on the elucidation of new structural conformations and functions of the sodium/potassium adenosine triphosphate synthase (Na/K ATPase), and especially elucidation of new binding sites and interactions. The present invention provides practical applications of several surprising structural and functional relationships between Na/K ATPase and compounds which interact with Na/K ATPase. Disclosure of these structures and relationships provides insight and practical solutions to chemically affecting not only the Na/K ATPase interactions, but also regulators known to be upstream and downstream.


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