The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 08, 2014
Filed:
Sep. 25, 2010
Andrew V. Schally, Miami Beach, FL (US);
Marta Zarandi, Miami Beach, FL (US);
Jozsef L. Varga, Miami Beach, FL (US);
Ren Zhi Cai, Miami, FL (US);
Andrew V. Schally, Miami Beach, FL (US);
Marta Zarandi, Miami Beach, FL (US);
Jozsef L. Varga, Miami Beach, FL (US);
Ren Zhi Cai, Miami, FL (US);
University of Miami, Miami, FL (US);
U.S.A. Represented by the Dept. of Veterans Affairs, Washington, DC (US);
Abstract
There is provided a novel series of synthetic analogs of hGH-RH(1-29)NH(SEQ ID NO: 1) and hGH-RH(1-30)NH. Of particular interest are those carrying PhAc, N-Me-Aib, Dca, Ac-Ada, Fer, Ac-Amc, Me-NH-Sub, PhAc-Ada, Ac-Ada-D-Phe, Ac-Ada-Phe, Dca-Ada, Dca-Amc, Nac-Ada, Ada-Ada, or CH—(CH)—CO-Ada, at the N-Terminus and β-Ala, Amc, Apa, Ada, AEA, AEP, ε-Lys(α-NH), Agm, Lys(Oct) or Ahx, at the C-terminus. These analogs inhibit the release of growth hormone from the pituitary in mammals as well as inhibit the proliferation of human cancers, and inhibit the hyperplastic and benign proliferative disorders of various organs, through a direct effect on the cancerous and non-malignant cells. The stronger inhibitory potencies of the new analogs, as compared to previously described ones, result from replacement of various amino acids.