The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 08, 2014
Filed:
Jan. 04, 2006
Irun R. Cohen, Rehovot, IL;
Alexandra Zanin-zhorov, Staten Island, NY (US);
Guy Tal, Tel-Aviv, IL;
Francisco Quintana, Buenos Aires, AR;
Meirav Pevsner, Karmiel-Yosef, IL;
Osnat Lider, Kfar Bilu B, IL;
Lihi Lider, Kfar Bilu B, IL;
Irun R. Cohen, Rehovot, IL;
Alexandra Zanin-Zhorov, Staten Island, NY (US);
Guy Tal, Tel-Aviv, IL;
Francisco Quintana, Buenos Aires, AR;
Meirav Pevsner, Karmiel-Yosef, IL;
Ofer Lider, Kfar Bilu B, IL;
Yeda Research and Development Co. Ltd., Rehovot, IL;
Abstract
The present invention provides novel uses for peptide p277—positions 437-460 of human heat shock protein 60 (HSP60)—in modulation of immune responses and inflammatory diseases. The invention further provides novel uses for HSP60 and p277 in the treatment or prevention of hepatic disorders. The invention discloses methods for treating, preventing or ameliorating the symptoms of T cell mediated inflammatory and autoimmune disorders, including hepatic disorders, which comprise administering to a subject in need thereof a composition comprising as an active ingredient an effective quantity of a molecule selected from: HSP60, p277, fragments, analogs, homologs and derivatives thereof, and nucleic acids encoding same. Also disclosed are T cell vaccination methods for treating or preventing T cell mediated disorders.