The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 08, 2014
Filed:
Sep. 12, 2008
Maximiliano Vasquez, Palo Alto, CA (US);
Michael Feldhaus, Belmont, MA (US);
Tillman U. Gerngross, Hanover, NH (US);
K. Dane Wittrup, Chestnut Hill, MA (US);
Maximiliano Vasquez, Palo Alto, CA (US);
Michael Feldhaus, Belmont, MA (US);
Tillman U. Gerngross, Hanover, NH (US);
K. Dane Wittrup, Chestnut Hill, MA (US);
Adimab, LLC, Lebanon, NH (US);
Abstract
The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences.