The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 08, 2014
Filed:
Apr. 04, 2011
Jeffrey G. Aaronson, Philadelphia, PA (US);
Stanley F. Barnett, North Wales, PA (US);
René Bartz, Lawrenceville, NJ (US);
Steven L. Colletti, Princeton Junction, NJ (US);
Vasant R. Jadhav, Harleysville, PA (US);
Aaron A. Momose, Blue Bell, PA (US);
Anthony W. Shaw, Harleysville, PA (US);
David M. Tellers, Lansdale, PA (US);
Thomas J. Tucker, North Wales, PA (US);
Weimin Wang, Churchville, PA (US);
Yu Yuan, Orlando, FL (US);
Jeffrey G. Aaronson, Philadelphia, PA (US);
Stanley F. Barnett, North Wales, PA (US);
René Bartz, Lawrenceville, NJ (US);
Steven L. Colletti, Princeton Junction, NJ (US);
Vasant R. Jadhav, Harleysville, PA (US);
Aaron A. Momose, Blue Bell, PA (US);
Anthony W. Shaw, Harleysville, PA (US);
David M. Tellers, Lansdale, PA (US);
Thomas J. Tucker, North Wales, PA (US);
Weimin Wang, Churchville, PA (US);
Yu Yuan, Orlando, FL (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
In an embodiment the instant invention discloses a modular composition comprising 1) an oligonucleotide; 2) one or more linkers, which may be the same or different, selected from Table 1, wherein the linkers are attached to the oligonucleotide at any 3' and/or 5′ end; 3) one or more peptides, which may be the same or different, selected from SEQ ID NOs: 1-59, wherein the peptides are attached to the linkers; and optionally one or more lipids, solubilizing groups and/or targeting ligands attached to the oligonucleotide.