The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 08, 2014
Filed:
Aug. 21, 2009
Birgit Schoeberl, Cambridge, MA (US);
Ulrik Nielsen, Quincy, MA (US);
Michael Feldhaus, Grantham, NH (US);
Arumugam Muruganandam, Bangalore, IN;
David Buckler, Chester, NJ (US);
Birgit Schoeberl, Cambridge, MA (US);
Ulrik Nielsen, Quincy, MA (US);
Michael Feldhaus, Grantham, NH (US);
Arumugam Muruganandam, Bangalore, IN;
David Buckler, Chester, NJ (US);
Merrimack Pharmaceuticals, Inc., Cambridge, MA (US);
Abstract
The present invention provides a novel class of antibodies and antigen binding fragments thereof that bind the extracellular domain of ErbB3 receptor and inhibit various ErbB3 functions. For example, the antibodies and antigen binding fragments described herein are capable of binding to the receptor designated ErbB3 and inhibiting EGF-like ligand mediated phosphorylation of the receptor. Such antibodies and antigen binding fragments thereof have the useful characteristic of inhibiting the proliferation of cancer cells expressing ErbB3.