The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 08, 2014
Filed:
Dec. 23, 2011
Motoichi Kurisawa, Singapore, SG;
LI Shan Wang, Singapore, SG;
Joo Eun Chung, Singapore, SG;
Fan Lee, Singapore, SG;
Keming Xu, Singapore, SG;
Hirohisa Yano, Chikushino, SG;
Motoichi Kurisawa, Singapore, SG;
Li Shan Wang, Singapore, SG;
Joo Eun Chung, Singapore, SG;
Fan Lee, Singapore, SG;
Keming Xu, Singapore, SG;
Hirohisa Yano, Chikushino, SG;
Agency for Science, Technology and Research, Singapore, SG;
Abstract
In a process of forming a hydrogel from a mixture comprising hydrogen peroxide (HO), horseradish peroxidase (HRP), and a polymer comprising a crosslinkable phenol group, the gelation rate in the solution and the crosslinking density in the hydrogel can be independently adjusted or controlled by selection of the molarity of HOand concentration of HRP in the solution when the molarity of HOis limited to be within a range and the concentration of HRP is limited to be above a threshold. A method for determining the range and threshold is disclosed. The hydrogel may be used to grow cells, in which case, the molarity of HOmay be selected to affect the differentiation or growth rate of the cells in the hydrogel. Also, the hydrogel system may be used for sustained delivery of a therapeutic protein, for example in the treatment of liver cancer, fibrosis or hepatitis.