The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 08, 2014
Filed:
Feb. 25, 2011
Anna Katrin Szardenings, Torrance, CA (US);
Wei Zhang, Los Angeles, CA (US);
Dhanalakshmi Kasi, Los Angeles, CA (US);
Anjana Sinha, San Diego, CA (US);
Umesh B. Gangadharmath, Los Angeles, CA (US);
Joseph C. Walsh, Pacific Palisades, CA (US);
Anna Katrin Szardenings, Torrance, CA (US);
Wei Zhang, Los Angeles, CA (US);
Dhanalakshmi Kasi, Los Angeles, CA (US);
Anjana Sinha, San Diego, CA (US);
Umesh B. Gangadharmath, Los Angeles, CA (US);
Joseph C. Walsh, Pacific Palisades, CA (US);
Eli Lilly and Company, Indianapolis, IN (US);
Abstract
Imaging agents of formulas (I)-(V) and methods for detecting neurological disorders comprising administering to a patient in need compounds of formulas (I)-(V) capable of binding to tau proteins and β-amyloid peptides are presented herein. The invention also relates to methods of imaging Aβ and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formulas (I)-(V) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders.