The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 01, 2014
Filed:
May. 31, 2012
Yaron Ilan, Jerusalem, IL;
Ehud Zigmond, Jerusalem, IL;
Richard B. Silverman, Northbrook, IL (US);
Hejun LU, Shanghai, CN;
Yaron Ilan, Jerusalem, IL;
Ehud Zigmond, Jerusalem, IL;
Richard B. Silverman, Northbrook, IL (US);
Hejun Lu, Shanghai, CN;
Hadasit Medical Research Services & Development, Ltd., Jerusalem, IL;
Northwestern University, Evanston, IL (US);
Abstract
The invention relates to inhibition of ornithine aminotransferase (OAT) for suppression of tumor cells proliferation. More particularly, the invention relates to methods of treatment of proliferative disorders by the selective inhibition of OAT, and further provides the use of OAT inhibitors, specifically, 5-amino-1,3-hexadienyl-carboxylic acid (Gabaculine), and Gabaculine analogue 8, for compositions and methods for the treatment of proliferative disorders such as hepatocellular carcinoma. The invention further provides methods and kits for the diagnosis of a pathologic proliferative disorder in a mammalian subject, based on determining the level of OAT expressed in a biological sample obtained from a subject.