The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 01, 2014
Filed:
Feb. 03, 2010
Hachiro Sugimoto, Kyoto, JP;
Jun Takahashi, Kyoto, JP;
Takashi Takahashi, Tokyo, JP;
Ichiro Hijikuro, Tokyo, JP;
Hachiro Sugimoto, Kyoto, JP;
Jun Takahashi, Kyoto, JP;
Takashi Takahashi, Tokyo, JP;
Ichiro Hijikuro, Tokyo, JP;
Kyoto University, Kyoto-Shi, JP;
Tokyo Institute of Technology, Tokyo, JP;
Abstract
The present invention provides a novel indoline derivative or a pharmacologically acceptable salt thereof or a solvate of the derivative or a salt thereof represented by the following formula (1) that has an excellent butyrylcholinesterase inhibitory activity. In the formula, Rrepresents an alkyl group, a cycloalkyl group, a heterocycloalkyl group, an aryl group, a heteroaryl group, an arylalkyl group, a heteroarylalkyl group, a cycloalkylalkyl group, a heterocycloalkylalkyl group, a dihydrofurylalkyl group, an alkenyl group, a tetrahydronaphthyl group, or an indanyl group; Rrepresents a hydrogen atom, an alkyl group, an arylalkyl group, a cycloalkylalkyl group, a heteroarylalkyl group, a heterocycloalkylalkyl group, an aryl group, or an acyl group; Reach independently represents a hydrogen atom, an alkyl group, or a dialkylaminocarbonyl group; Reach independently represents a hydrogen atom or an alkyl group; and Rrepresents a hydrogen atom or an alkyl group. Each functional group may have a substituent.