The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 01, 2014
Filed:
Sep. 23, 2011
Kenneth C. Anderson, Wellesley, MA (US);
Teru Hideshima, Brookline, MA (US);
Constantine S. Mitsiades, Boston, MA (US);
Nicholas Mitsiades, Roxbury, MA (US);
Kenneth C. Anderson, Wellesley, MA (US);
Teru Hideshima, Brookline, MA (US);
Constantine S. Mitsiades, Boston, MA (US);
Nicholas Mitsiades, Roxbury, MA (US);
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
Abstract
The present invention relates to therapeutic compositions for treating cancer or preventing the growth of cancer cells, e.g., tumor growth, in a subject. The present invention also relates to methods for treating cancer, e.g., inhibiting tumor growth, in a subject who has become resistant to treatment, by administering to a subject an effective amount of a proteasome inhibitor and an effective amount of a therapeutic agent, e.g., a chemotherapeutic agent. The present invention further relates to methods for purging bone marrow, i.e., removing cancer cells from bone marrow, by exposing the bone marrow cells to a proteasome inhibitor and a therapeutic agent, e.g., a chemotherapeutic agent.