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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8685947 B1

PDFFull Text
Date of Patent:
Apr. 01, 2014

Filed:

Aug. 25, 2011

Compositions and methods for loop diuretics with consistent bioavailability

Applicants:

Edith Mathiowitz, Brookline, MA (US);

Bryan Laulicht, Great Neck, NY (US);

Inventors:

Edith Mathiowitz, Brookline, MA (US);

Bryan Laulicht, Great Neck, NY (US);

Assignee:

Brown University, Providence, RI (US);

Attorneys:

Lawson & Weitzen, LLP

Sonia K. Guterman

Anna E. Stanford

Primary Examiner:

James D Anderson

Assistant Examiner:

William Lee

Int. Cl.
CPC ...
A01N 51/00 (2006.01); A61K 31/655 (2006.01); A61K 47/32 (2006.01); B32B 5/16 (2006.01); B32B 9/00 (2006.01); B32B 15/02 (2006.01); B32B 17/02 (2006.01); B32B 19/00 (2006.01); B32B 21/02 (2006.01); B32B 23/02 (2006.01); B32B 27/02 (2006.01); C07D 307/02 (2006.01);
U.S. Cl.
CPC ...
Abstract

Diuretic bioactivity profiles of phase inversion micronized furosemide and furosemide co-precipitated with Eudragit L100, and mixtures of those formulations with stock furosemide, reduced or eliminated the rapid spike in diuresis associated with immediate release formulations and maintained cumulative urine output. Of the formulations tested, each of a mixture of micronized furosemide with stock furosemide, and Eudragit L100 polymer with stock furosemide demonstrated optimal diuretic bioactivity profiles in subjects.

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Mathiowitz, Edith. (2014). Compositions and methods for loop diuretics with consistent bioavailability (U.S. Patent No. 8685947). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/8685947

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