The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 01, 2014
Filed:
Nov. 06, 2009
Wei-zen Wei, Grosse Pointe Farms, MI (US);
Gen Sheng Wu, Troy, MI (US);
Marie P. Piechocki, Fraser, MI (US);
Richard F. Jones, Fayetteville, NY (US);
Wei-Zen Wei, Grosse Pointe Farms, MI (US);
Gen Sheng Wu, Troy, MI (US);
Marie P. Piechocki, Fraser, MI (US);
Richard F. Jones, Fayetteville, NY (US);
Wayne State University, Detroit, MI (US);
Abstract
The invention provides therapeutics and methods to induce a mammalian host, including a human, to produce antibodies, which agonize death receptors and cause the apoptotic death of target cells within the host's body. The therapeutics are vaccine compositions, including genetic vaccines encoding death receptor antigens of the tumor necrosis factor receptor family. Also provided are means and methods for overcoming host immunological tolerance to death receptors. The vaccines are useful against cancer cells and other death receptor bearing target cells within the host, and can be used in both therapeutic and prophylactic settings. The vaccines are also useful for diagnostic testing of the immunocompetence of a host.