The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 01, 2014
Filed:
Apr. 10, 2012
Donna G. Albertson, Lafayette, CA (US);
Daniel Pinkel, Walnut Creek, CA (US);
Colin Collins, San Rafael, CA (US);
Joe W. Gray, San Francisco, CA (US);
Bauke Ylstra, San Francisco, CA (US);
Donna G. Albertson, Lafayette, CA (US);
Daniel Pinkel, Walnut Creek, CA (US);
Colin Collins, San Rafael, CA (US);
Joe W. Gray, San Francisco, CA (US);
Bauke Ylstra, San Francisco, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer (e.g., breast cancer). Using this information, this invention provides methods of detecting a predisposition to cancer in an animal. The methods involve (i) providing a biological sample from an animal (e.g. a human patient); (ii) detecting the level of CYP24 within the biological sample; and (iii) comparing the level of CYP24 with a level of CYP24 in a control sample taken from a normal, cancer-free tissue where an increased level of CYP24 in the biological sample compared to the level of CYP24 in the control sample indicates the presence of said cancer in said animal.