The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 01, 2014
Filed:
Apr. 30, 2010
Xiang Zhang, Alamo, CA (US);
Jonathan A. Ellman, Guilford, CT (US);
Fanqing Frank Chen, Moraga, CA (US);
Kai-hang Su, Seoul, KR;
Qi-huo Wei, Kent, OH (US);
Cheng Sun, Evanston, IL (US);
Xiang Zhang, Alamo, CA (US);
Jonathan A. Ellman, Guilford, CT (US);
Fanqing Frank Chen, Moraga, CA (US);
Kai-Hang Su, Seoul, KR;
Qi-Huo Wei, Kent, OH (US);
Cheng Sun, Evanston, IL (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
A nanoplasmonic resonator (NPR) comprising a metallic nanodisk with alternating shielding layer(s), having a tagged biomolecule conjugated or tethered to the surface of the nanoplasmonic resonator for highly sensitive measurement of enzymatic activity. NPRs enhance Raman signals in a highly reproducible manner, enabling fast detection of protease and enzyme activity, such as Prostate Specific Antigen (paPSA), in real-time, at picomolar sensitivity levels. Experiments on extracellular fluid (ECF) from paPSA-positive cells demonstrate specific detection in a complex bio-fluid background in real-time single-step detection in very small sample volumes.