The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 01, 2014
Filed:
Jun. 18, 2012
Aadel Chaudhuri, Santa Clara, CA (US);
Alex Steven SO, Los Angeles, CA (US);
David Baltimore, Pasadena, CA (US);
Ryan M. O'connell, Salt Lake City, UT (US);
Aadel Chaudhuri, Santa Clara, CA (US);
Alex Steven So, Los Angeles, CA (US);
David Baltimore, Pasadena, CA (US);
Ryan M. O'Connell, Salt Lake City, UT (US);
California Institute of Technology, Pasadena, CA (US);
Abstract
The present disclosure relates to regulation of macrophage activation by delivering of miRNAs, for example miR-125b or anti-miR-125b, to macrophages. For example, in some embodiments, macrophage activation can be elevated or reduced by administering miR-125b or anti-miR-125b oligonucleotides. Also disclosed are methods for promoting T cell activation and method for treating various disorders such as tumor and autoimmune diseases.