The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 25, 2014
Filed:
Aug. 01, 2007
Patrick Henry Beusker, Nijmegen, NL;
Henri Johannes Spijker, Nijmegen, NL;
Johannes Albertus Frederikus Joosten, Nijmegen, NL;
Tijl Huijbregts, Nijmegen, NL;
Franciscus Marinus Hendrikus DE Groot, Nijmegen, NL;
Patrick Henry Beusker, Nijmegen, NL;
Henri Johannes Spijker, Nijmegen, NL;
Johannes Albertus Frederikus Joosten, Nijmegen, NL;
Tijl Huijbregts, Nijmegen, NL;
Franciscus Marinus Hendrikus de Groot, Nijmegen, NL;
Syntarga B.V., Nijmegen, NL;
Abstract
This invention relates to novel agents that are analogs of the DNA-alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and their conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.