The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 25, 2014
Filed:
Dec. 10, 2007
Mark A. Emalfarb, Jupiter, FL (US);
Peter J. Punt, Houten, NL;
Cornelia Van Zeijl, Vleuten-de-Meern, NL;
Cornelius Van Den Hondel, Gouda, NL;
Jan Verdoes, Zeist, NL;
Richard P. Burlingame, Jupiter, FL (US);
Mark A. Emalfarb, Jupiter, FL (US);
Peter J. Punt, Houten, NL;
Cornelia Van Zeijl, Vleuten-de-Meern, NL;
Cornelius Van Den Hondel, Gouda, NL;
Jan Verdoes, Zeist, NL;
Richard P. Burlingame, Jupiter, FL (US);
Dyadic International (USA), Inc., Jupiter, FL (US);
Abstract
The invention provides a method for the expression and subsequent screening of DNA libraries, particularly synthetic, genomic, and cDNA libraries, in filamentous fungal hosts. In particular, the invention provides vectors, host strains, and a method for the expression and screening of complex DNA libraries, including, but not limited to, combinatory (combinatorial) libraries expressing one, two or more variable constituents and/or prepared from two or more sublibraries (e.g., for the expression and screening of immunoglobulin (including fragments and derivatives of whole immunoglobulin proteins) and other receptor or complex DNA libraries or libraries of libraries). The invention is useful for the expression and screening for a large variety of proteins and protein complexes, including human proteins. The present invention also relates to novel fungal protease sequences.