The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 25, 2014
Filed:
Jul. 17, 2008
Jonathan Alexander Terrett, Sunnyvale, CA (US);
Li-sheng LU, Mountain View, CA (US);
Haichun Huang, Fremont, CA (US);
Dapeng Yao, Milpitas, CA (US);
Chin Pan, Los Altos, CA (US);
Heidi Leblanc, Mountain View, CA (US);
Timothy Sproul, Livermore, CA (US);
Mark Yamanaka, Pleasanton, CA (US);
Jonathan Alexander Terrett, Sunnyvale, CA (US);
Li-Sheng Lu, Mountain View, CA (US);
Haichun Huang, Fremont, CA (US);
Dapeng Yao, Milpitas, CA (US);
Chin Pan, Los Altos, CA (US);
Heidi Leblanc, Mountain View, CA (US);
Timothy Sproul, Livermore, CA (US);
Mark Yamanaka, Pleasanton, CA (US);
Medarex, L.L.C., Princeton, NJ (US);
Abstract
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Glypican-3 with high affinity. Nucleic acid molecules encoding Glypican-3 antibodies, expression vectors, host cells and methods for expressing the Glypican-3 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the Glypican-3 antibodies are also provided. Methods for detecting Glypican-3, as well as methods for treating various Glypican-3-related conditions, including hepatocellular cancer, are disclosed.