The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 25, 2014
Filed:
Nov. 19, 2008
Benjamin J. Luft, East Setauket, NY (US);
John J. Dunn, Bellport, NY (US);
Shohei Koide, Chicago, IL (US);
Catherine L. Lawson, Piscataway, NJ (US);
Benjamin J. Luft, East Setauket, NY (US);
John J. Dunn, Bellport, NY (US);
Shohei Koide, Chicago, IL (US);
Catherine L. Lawson, Piscataway, NJ (US);
Brookhaven Sciences Associates, LLC, Upton, NY (US);
University of Rochester, Rochester, NY (US);
Research Foundation of the State University of New York, Stony Brook, NY (US);
Abstract
Provided herein are OspA polypeptides from Lyme Disease-causinghaving certain alteration(s). In one embodiment, the alteration(s) increase the conformational stability of the OspA polypeptide containing the alteration(s) while maintaining at least some of the antigenicity of the corresponding unaltered OspA polypeptide. In another embodiment, the altered OspA polypeptide has reduced cross-reactivity to hLFA-1, as compared to the corresponding unaltered OspA polypeptide.