The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 25, 2014
Filed:
Aug. 29, 2011
Joan Gil Santano, Castelldefels, ES;
Rodolfo Lavilla Grifols, Castelldefels, ES;
Fernando Albericio Palomera, Barcelona, ES;
Alba Pérez Perarnau, Sabadell, ES;
Sara Preciado Gallego, L'Hospitalet de Llobregat, ES;
Diana MA González Gironès, Bigues i Riells, ES;
Daniel Iglesias Serret, Barcelona, ES;
Rosario Ramón Albalate, L'Hospitalet de Llobregat, ES;
Joan Gil Santano, Castelldefels, ES;
Rodolfo Lavilla Grifols, Castelldefels, ES;
Fernando Albericio Palomera, Barcelona, ES;
Alba Pérez Perarnau, Sabadell, ES;
Sara Preciado Gallego, L'Hospitalet de Llobregat, ES;
Diana Ma González Gironès, Bigues i Riells, ES;
Daniel Iglesias Serret, Barcelona, ES;
Rosario Ramón Albalate, L'Hospitalet de Llobregat, ES;
Universitat de Barcelona, Barcelona, ES;
Fundacio Privada Institut d'Inbestigacio Biomedica de Bell Vitge, l'Hospitalet de Llobregat, ES;
Fundacio Privada Institute de Recerca Biomedica de Barcelona, Barcelona, ES;
Fundacio Privada Parc Cientific de Barcelona, Barcelona, ES;
Abstract
Compounds of formula (I) or their pharmaceutically acceptable salts, or their stereoisomers or mixtures of stereoisomers, where: Ris selected from the group consisting of: phenyl, and phenyl mono-, di-, or tri-substituted by a radical independently selected from the group consisting of F, Cl, Br, I, (C-C)-alkyl, COO—(C-C)-alkyl, and (C-C)-alkoxy; and Ris a radical selected from the same group as R, further including a phenyl substituted in 4-position by a radical independently selected from the group consisting of —O(CH)CONH(CH)CHand OCHCOOC(CH), a biphenyl-4-yl, thiazol-2-yl, and a thiazol-2-yl mono- or di-substituted by a radical selected from F and phenyl; inhibit cell proliferation of tumor cells independently of p53 protein and may also induce apoptosis in several tumor cells independently of p53 protein, being useful for the treatment of several types of cancer.